Supplementing Safely:

5 Questions to Ask before using a supplement

Short Read

  • There are quality supplements that, when used appropriately, are perfectly safe
  • Inappropriate use and poor quality of supplements can have safety issues
  • There are important questions you should always ask before using a supplement
  • It's best to consult with a trusted and licensed professional with knowledge about supplements
  • Quality supplements are perfectly safe and can play an important role in healthy living when used appropriately

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Nutritional supplements are sometimes on the receiving end of negative publicity. You've probably seen headlines commenting on the dangers of supplements, such as those following a 2015 study showing that around 23,000 emergency room visits every year are related to the use (or misuse) of nutritional supplements - especially energy and weight-loss supplements.1

The problem with stories like this is that they can paint a negative picture for all supplements - including some high quality supplements that are perfectly safe and play an important role in healthy living.

A common scenario

Several years ago, I had an experience that highlights a major contributing factor to the safety of supplements.

A friend of mine was considering using a popular Detox/Cleanse supplement.  Knowing that I was a pharmacist who specializes in supplements, they decided to ask my thoughts before using the product. 

I was happy they asked my opinion, because so many people will blindly take a supplement without even reading the label, let alone asking a professional their opinion. I gladly reviewed the product and gave the following feedback:

“This product contains a lot of refined sugars that I do not believe would be helpful in cleansing or detoxing the body. There are also several ingredients that I would never take or recommend because of documented cases of liver toxicity and other adverse effects.  In my professional opinion, I would not personally take the product, and I don’t recommend that you use the product - there are better options available.”

After hearing my opinion, the friend replies, “Well, I’ve already paid for it so I’ll probably still use it.” I was obviously frustrated – but what happened next I found to be even more troubling. 

The friend proceeded to tell me that they were an independent distributor of this product and they sell it to people as a way to make some extra income.  They had absolutely no medical or scientific background and had admitted that they hadn't even read the ingredient label. Yet they were comfortable not only taking it against professional medical advice but also selling it to other people.

To me, this paints a clear picture of why there are people showing up in the emergency room because of inappropriate use of supplements.

Asking the right questions:

There are some key questions you can ask before deciding to use a supplement that can help improve your safety and ultimately help you achieve your desired outcomes.  Ask these 5 questions about any product you decide to use, and always be sure to discuss the decision with a trusted healthcare provider.

  1. Where was it made?

    Products manufactured overseas tend to have less regulation during the manufacturing process and are more likely to contain contaminants and adulterants.2–5  While these problems can still occur with American manufacturers, there are several reputable companies that hold themselves to higher standards, following regulatory guidelines similar to those required for pharmaceutical agents.5–8

    All Pinnaclife products are manufactured in the United States following current good manufacturing and laboratory procedures (cGMP, cGLP) with third-party testing to confirm purity and potency of all raw materials and finished products.

  2. What does it contain?

    Always read the labels before putting something into your body.  If you don’t know what an ingredient is, ask a trusted and licensed healthcare provider.  If they don’t know what it is, then consider that to be a red flag.

    For example, if you see ingredients like Gymnema sylvestre, blue vervain, gamma-amino-butyric acid, Garcinia cambogia, schisandra, or Cynanchum stautoni - do you or your healthcare provider know what they are?  Are they safe to use in somebody with high blood pressure?  Are they safe in a person that becomes dehydrated and overexerted during a workout?

    In comparison, most healthcare providers will recognize and be comfortable with ingredients from well-known sources like olives, green tea, broccoli, grapes, and turmeric because they have a long established history of safe use in all populations plus more scientific evidence supporting their use. Also - if you've eaten grapes with no adverse reaction, there's a pretty good chance you'll tolerate grape extracts in a supplement. But how do you know if you're allergic to Garcinia cambogia?

  3. How was the product developed?

    Some supplement manufacturers take the “shotgun approach” to creating their supplements.  Think of it as somebody searching for “natural sleep remedies” on the internet and then taking every single ingredient that pops up on the search and putting it into a capsule.

    The product was made with limited research into safety and efficacy, little thought into the biochemical plausibility of the purported effect of each ingredient, and no research into how the ingredients all interact when combined together.

    In comparison, each ingredient found in Pinnaclife supplements was heavily researched and the products were developed based on scientific evidence with the support of biochemists, physicians, pharmacists, dietitians, and more.  The products are based on patented scientific formulas, not the results of a quick internet search.

  4. Who recommended I use the product?

    Always consider the educational and professional background of the person recommending you use a supplement and whether or not they are a licensed professional that carries liability for their recommendation.

    Licensed professionals including doctors, pharmacists, and dietitians spent years studying the complex chemistry of the body to understand how nutrients are absorbed, metabolized, utilized, and excreted from the body.  They have intimate understandings of how certain medical conditions or medications might alter your body’s chemistry and how that could affect the safety of a supplement.

    The best way to improve your safety when using supplements is to rely on input from licensed medical professionals that have a working knowledge in the subject.  They can also help you determine if information is accurate, reliable, and/or relevant to your situation.

  5. Why do I need it?

    It’s very important to establish why you are making the decision to use a nutritional supplement in the first place.  Perhaps it's a general reason like improving the nutrient content of your diet with a multivitamin. Maybe it's something more specific such as using melatonin to help you sleep at night or curcumin to reduce inflammation.

    Regardless of your reason, it is best to establish why you are considering using a supplement.  This can help you determine if you have reasonable goals and expectations from the product and also to determine if you are experiencing the outcomes you desired.

    For example, consider a weight loss supplement:  do you absolutely need it to lose weight?  Is it going to do anything that a proper diet and exercise wouldn’t do?  Do you expect to achieve dramatic weight loss because of this pill?  Is it worth the risk considering that diet pills are one of the top offenders for supplement-related toxicity and emergency room visits?1,9,10

You can supplement safely

Nutritional supplements do play an important role in promoting optimum health, but the decision to use them needs to be taken seriously and discussed with a licensed healthcare provider.11 Almost all major safety concerns regarding supplements can be eliminated by simply asking and considering the above questions and seeking out information from reliable sources.  Remember that not all supplements are the same, and you can easily find and safely use quality supplements that are trusted and recommended by licensed healthcare providers.

    1. Geller AJ, Shehab N, Weidle NJ, et al. Emergency Department Visits for Adverse Events Related to Dietary Supplements. N Engl J Med. 2015;373:1531–40.
    2. Cassileth BR, Heitzer M, Wesa K. The Public Health Impact of Herbs and Nutritional Supplements. Pharm Biol. 2009;47(8):761–767.
    3. Ventola CL. Current Issues Regarding Complementary and Alternative Medicine ( CAM ) in the United States Part 2 : Regulatory and Safety Concerns and Proposed Governmental Policy Changes with Respect to Dietary Supplements. P&T. 2010;35(9):514–522.
    4. Dunnick JK, Nyska A. The toxicity and pathology of selected dietary herbal medicines. Toxicol Pathol. 2013;41(2):374–86.
    5. Rotblatt MD. Herbal medicine : a practical guide to safety and quality assurance. WJM. 1999;171:172–175.
    6. Van Breeman RB, Fong HHS, Farnsworth NR. The Role of Quality Assurance and Standardization in the Safety of Botanical Dietary Supplements. Chem Res Toxicol. 2008;20(4):577–582.
    7. Newmaster SG, Grguric M, Shanmughanandhan D, Ramalingam S, Ragupathy S. DNA barcoding detects contamination and substitution in North American herbal products. BMC Med. 2013;11(1):222.
    8. Cohen P a. American roulette--contaminated dietary supplements. N Engl J Med. 2009;361(16):1523–5.
    9. Yen M, Ewald MB. Toxicity of weight loss agents. J Med Toxicol. 2012;8:145–52.
    10. Egras AM, Hamilton WR, Lenz TL, Monaghan MS. An evidence-based review of fat modifying supplemental weight loss products. J Obes. 2011;2011(Article ID 297315):1–7.
    11. Elder C, Mossbrucker P, Davino-Ramaya CM, et al. Integrating herbs and supplements in managed care: a pharmacy perspective. Perm J. 2008;12(3):52–8.
  • Kyle Hilsabeck, PharmD., is the Vice President of Pharmaceutical Affairs at McCord Holdings and licensed by the Iowa Board of Pharmacy.  He completed bachelors degrees in biology and biochemistry at Wartburg College before earning his Doctorate of Pharmacy from the University of Iowa College of Pharmacy. Upon graduation, he completed a community pharmacy practice residency through the University of Iowa where he focused primarily on nutritional aspects of care including the use of vitamin, mineral, and herbal supplements.  He has taught courses for the University of Iowa College of Pharmacy on vitamins, minerals, herbs, and nutritional supplements and given many presentations on the subject as well.  He has a passion for improving patient care specifically with regards to the safety and quality of the nutritional supplements and health information people use. 


Disclaimer: These statements have not been reviewed by the FDA. These products are dietary supplements and are not intended to treat, cure, or prevent any disease. The decision to use these products should be discussed with a trusted healthcare provider. The authors and the publisher of this work have made every effort to use sources believed to be reliable to provide information that is accurate and compatible with the standards generally accepted at the time of publication. The authors and the publisher shall not be liable for any special, consequential, or exemplary damages resulting, in whole or in part, from the readers’ use of, or reliance on, the information contained in this article. The publisher has no responsibility for the persistence or accuracy of URLs for external or third party Internet websites referred to in this publication and does not guarantee that any content on such websites is, or will remain, accurate or appropriate.